Astragale

(1) Kuo YH, Tsai WJ, Loke SH, Wu TS, Chiou WF. Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. J Ethnopharmacol. 2009 Feb 25;122(1):28-34. doi: 10.1016/j.jep.2008.11.025. Epub 2008 Dec 6. PMID: 19103273. (https://pubmed.ncbi.nlm.nih.gov/19103273/)

(2) Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Gu Y. Astragalus embranaceus extract activates immune response in macrophages via heparanase. Molecules. 2012 Jun 13;17(6):7232-40. doi: 10.3390/molecules17067232. PMID: 22695229; PMCID: PMC6268577. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268577/)

(3) Zhang Q, Gao WY, Zhang Y, Chen BY, Chen Z, Zhang WS, Man SL. Protective effects of astragalus extract against intermittent hypoxia-induced hippocampal neurons impairment in rats. Chin Med J (Engl). 2013;126(8):1551-4. PMID: 23595393. (https://pubmed.ncbi.nlm.nih.gov/23595393/)

(4) Kim MH, Kim SH, Yang WM. Beneficial effects of Astragaloside IV for hair loss via inhibition of Fas/Fas L-mediated apoptotic signaling. PLoS One. 2014 Mar 27;9(3):e92984. doi: 10.1371/journal.pone.0092984. PMID: 24676213; PMCID: PMC3968031. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968031/)

(5) Zhang G, Zhou SM, Zheng SJ, Liu FY, Gao YQ. Astragalus on the anti-fatigue effect in hypoxic mice. Int J Clin Exp Med. 2015 Aug 15;8(8):14030-5. PMID: 26550363; PMCID: PMC4613048. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613048/)

(6) Dun C, Liu J, Qiu F, Wu X, Wang Y, Zhao Y, Gu P. Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model. Neuropsychiatr Dis Treat. 2016 Jul 1;12:1617-21. doi: 10.2147/NDT.S106123. PMID: 27445477; PMCID: PMC4936836. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936836/)

(7) Liu P, Zhao H, Luo Y. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging Dis. 2017 Dec 1;8(6):868-886. doi: 10.14336/AD.2017.0816. PMID: 29344421; PMCID: PMC5758356. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758356/)

(8) Baek Y, Kim H, Mun S, Lee S. Three-Component Herbal Tea Alleviates Prolonged Fatigue and Improves Sleep Quality: A Randomized Controlled Pilot Study. Explore (NY). 2018 Nov;14(6):420-423. doi: 10.1016/j.explore.2018.05.001. Epub 2018 Aug 2. PMID: 30482676. (https://pubmed.ncbi.nlm.nih.gov/30482676/)

(9) Berezutsky MA, Durnova NA, Vlasova IA. [Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus (review).]. Adv Gerontol. 2019;32(5):702-710. Russian. PMID: 32145159. (https://pubmed.ncbi.nlm.nih.gov/32145159/)

(10) Guinobert I, Blondeau C, Colicchio B, Oudrhiri N, Dieterlen A, Jeandidier E, Deschenes G, Bardot V, Cotte C, Ripoche I, Carde P, Berthomier L, M'Kacher R. The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol. Biomedicines. 2020 Feb 12;8(2):31. doi: 10.3390/biomedicines8020031. PMID: 32059353; PMCID: PMC7168059. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168059/)

(11) Sun Q, Shi P, Lin C, Ma J. Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats. Front Bioeng Biotechnol. 2020 Dec 23;8:616759. doi: 10.3389/fbioe.2020.616759. PMID: 33425879; PMCID: PMC7785889. (https://pubmed.ncbi.nlm.nih.gov/33425879/)

(12) Kang X, Su S, Hong W, Geng W, Tang H. Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury. Front Neurosci. 2021 Nov 16;15:755902. doi: 10.3389/fnins.2021.755902. PMID: 34867166; PMCID: PMC8637115. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637115/)

(13) Sheik A, Kim K, Varaprasad GL, Lee H, Kim S, Kim E, Shin JY, Oh SY, Huh YS. The anti-cancerous activity of adaptogenic herb Astragalus membranaceus. Phytomedicine. 2021 Oct;91:153698. doi: 10.1016/j.phymed.2021.153698. Epub 2021 Aug 5. PMID: 34479785. (https://pubmed.ncbi.nlm.nih.gov/34479785/)

(14) Li X, Zhao T, Gu J, Wang Z, Lin J, Wang R, Duan T, Li Z, Dong R, Wang W, Hong KF, Liu Z, Huang W, Gui D, Zhou H, Xu Y. Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis. Chin Med. 2022 Feb 12;17(1):22. doi: 10.1186/s13020-022-00578-8. PMID: 35151348; PMCID: PMC8840557. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840557/)

(15) Wang X-Y, Wang R-C, Qu Z-Y, Zhu Y-Z and Li Y-L (2022) Advances on immunoregulation effect of astragalus polysaccharides. Front. Nat. Prod. 1:971679. doi: 10.3389/fntpr.2022.971679 (https://www.frontiersin.org/articles/10.3389/fntpr.2022.971679/full)

(16) Yao M, Zhang L, Wang L. Astragaloside IV: A promising natural neuroprotective agent for neurological disorders. Biomed Pharmacother. 2023 Mar;159:114229. doi: 10.1016/j.biopha.2023.114229. Epub 2023 Jan 16. PMID: 36652731. (https://pubmed.ncbi.nlm.nih.gov/36652731/)

(17) Kim MH, Jin SC, Baek HK, Yang WM. Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway. Curr Issues Mol Biol. 2023 Oct 26;45(11):8607-8621. doi: 10.3390/cimb45110541. PMID: 37998718; PMCID: PMC10670826. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670826/)

(18) Xueling Zhang, Xixi Qu, Yu Zou; The Effect of Astragalus on Humoral and Cellular Immune Response: A Systematic Review and Meta-Analysis of Human Studies. Complement Med Research 28 December 2023; 30 (6): 535–543. https://doi.org/10.1159/000534826 (https://karger.com/cmr/article-abstract/30/6/535/869772/The-Effect-of-Astragalus-on-Humoral-and-Cellular)

(19) Wong, Yue-Ching & Chen, Ying-Ju & Li, Po-Hsien & Yang, Mei-Due & Lin, Liang-Hung & Wang, Teng-Hsu & Huang, Ping-Hsiu & Chou, Ming-Yu & Wang, Ming-Fu. (2023). Enhanced anti-fatigue and exercise performances due to Huáng qí polysaccharide supplementation in mice. Arabian Journal of Chemistry. 17. 105583. 10.1016/j.arabjc.2023.105583. (https://www.sciencedirect.com/science/article/pii/S1878535223010456)

(20) Su M, Tang T, Tang W, Long Y, Wang L, Liu M. Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review. Front Immunol. 2023 Aug 10;14:1243834. doi: 10.3389/fimmu.2023.1243834. PMID: 37638043; PMCID: PMC10450032. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450032/)