Gotu kola

(1) Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol. 2000 Dec;20(6):680-4. doi: 10.1097/00004714-200012000-00015. PMID: 11106141. (

(2) Xu Y, Cao Z, Khan I, Luo Y. Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide. J Alzheimers Dis. 2008 Apr;13(3):341-9. doi: 10.3233/jad-2008-13311. PMID: 18431001. (

(3) Qinna N, Taha H, Matalka KZ, Badwan AA. A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals. Int J Impot Res. 2009 Sep-Oct;21(5):315-20. doi: 10.1038/ijir.2009.18. Epub 2009 Jun 4. PMID: 19494825. (

(4) Gohil KJ, Patel JA, Gajjar AK. Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian J Pharm Sci. 2010 Sep;72(5):546-56. doi: 10.4103/0250-474X.78519. PMID: 21694984; PMCID: PMC3116297. (

(5) Chong NJ, Aziz Z. A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency. Evid Based Complement Alternat Med. 2013;2013:627182. doi: 10.1155/2013/627182. Epub 2013 Feb 21. PMID: 23533507; PMCID: PMC3594936. (

(6) Farhana KM, Malueka RG, Wibowo S, Gofir A. Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke. Evid Based Complement Alternat Med. 2016;2016:2795915. doi: 10.1155/2016/2795915. Epub 2016 Jun 1. PMID: 27340413; PMCID: PMC4908235. (

(7) Choi MJ, Zheng HM, Kim JM, Lee KW, Park YH, Lee DH. Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats. Mol Med Rep. 2016 Nov;14(5):4521-4528. doi: 10.3892/mmr.2016.5809. Epub 2016 Oct 5. PMID: 27748812; PMCID: PMC5101987. (

(8) Choi YM, An S, Lee J, Lee JH, Lee JN, Kim YS, Ahn KJ, An IS, Bae S. Titrated extract of Centella asiatica increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells. Biosci Biotechnol Biochem. 2017 Dec;81(12):2323-2329. doi: 10.1080/09168451.2017.1385383. Epub 2017 Oct 16. PMID: 29032741. (

(9) Park KS. Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms. Evid Based Complement Alternat Med. 2021 Nov 20;2021:5462633. doi: 10.1155/2021/5462633. PMID: 34845411; PMCID: PMC8627341. (

(10) Jeong, Y.J.; Jeon, H.; Kang, S.C. A Randomized, Double-Blind, Placebo-Controlled Parallel Study on the Efficacy and Safety of Centella asiatica L. Extract for Reducing Alanine Transaminase (ALT) Level in Subjects with Elevated ALT. Appl. Sci. 2021, 11, 11498. (

(11) Phoemsapthawee J, Ammawat W, Prasertsri P, Sathalalai P, Leelayuwat N. Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone? - a randomized controlled study. J Exerc Rehabil. 2022 Oct 26;18(5):330-342. doi: 10.12965/jer.2244388.194. PMID: 36420467; PMCID: PMC9650315. (

(12) Sahraei R, Aminyavari S, Hosseini M, Hassanzadeh-Taheri M, Foadoddini M, Saebipour MR. The Ameliorative Impact of Centella asiatica on the Working Memory Deficit in Streptozotocin-induced Rat Model of Alzheimer Disease. Basic Clin Neurosci. 2022 Jan-Feb;13(1):25-34. doi: 10.32598/bcn.2021.144.4. Epub 2022 Jan 1. PMID: 36589020; PMCID: PMC9790102. (
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